Principal Scientist, Pharmacology

As a member of the pharmacology group, we seek a scientifically curious and motivated individual with the ability

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to work in a fast-paced environment. The Principal Scientist will develop and execute the bioanalytical method development to support nonclinical and clinical sample analysis, as well as the transfer of assays to CRO’s.  In addition, the incumbent will support in vitro and in vivo pharmacology by using ELISA, Octet, flow cytometry or cell-based assays, as well as leading and conducting animal studies with CRO’s.

 

This position is hands-on and requires the effective study execution, communication, and documentation of results that enable the advancement of novel research molecules toward development candidates. Strong candidates will be creative, collaborative, and passionate about drug discovery and development. Expertise in tumor biology, immunology as well as pharmacology are required. As a strategic team member, you will directly support decision-making for pipeline programs as they progress from early research through an IND and into the clinic.

 

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

  • Identification, development and execution of in vitro assays to support both in vivo and in vitro pharmacology studies.
  • Independent design and execution of bioanalytical assays from assay development, qualification (as required), sample analysis, data analysis, report and SOP drafting (as required).
  • Independent management of bioanalytical assay outsourcing activities from assay transfer to sample analysis and report finalization.
  • Analyzation and presentation of experimental data using Prism, Excel, MS Office or similar software, along with delivery of findings to cross-functional groups.
  • Training and supporting junior team members to manage and execute complex experimental testing.
  • Producing detailed documentation of experiments within a lab notebook and electronically.
  • Effective scheduling and prioritization of workload within a fast-paced, multi-tasking environment.
  • Other duties as assigned.

 

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

  • PhD in Immunology, Cell Biology, Biotechnology, or a related discipline + at least 4 years of drug discovery experience, MS + 6 to 8 years of drug discovery experience, or BS + 10 to 12 years of drug discovery experience in an industry setting is required.
  • Extensive experience in ligand binding assay development, assay outsourcing, and qualification/validation is required.
  • Experience working with external CROs on bioanalytical assays and non-human primate studies (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly desirable.
  • Experience of processing and analyzing animal model samples and human clinical samples would be a
  • Strong understanding and prior experience working in immune
  • Hands-on expertise with standard lab techniques such as ELISA, MSD, Flow cytometry, and cell culture.
  • Competence in data analysis tools (Excel, GraphPad).
  • Strong analytical and critical thinking skills with the ability to work in a fast-paced
  • Strong analytical skills and ability to work in a highly collaborative
  • Excellent written and oral communication
  • Ability to travel up to 20% of the time.

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