Scientist, Downstream Process Development

Job Description

As a member of the Process Development, CMC group, the Scientist will contri

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bute to the development and implementation of downstream purification processes to enable the advancement of Janux therapeutic candidates from Research through Clinical development. The successful job candidate will contribute to the development and technical transfer of purification processes to Contract Development and Manufacturing Organizations (CDMOs) for clinical manufacturing.

 

 

Essential Functions and Responsibilities:

  • Design and perform experiments to identify and establish operating and performance parameters for purification steps and overall processes.
  • Execute lab-scale process development and material generation activities to support pre-clinical studies and technical transfer to CDMOs.
  • Perform experiments and interpret results to evaluate process parameters for individual unit operations.
  • Prepare SOPs and technical reports and maintain appropriate records of experiments.
  • Responsible for operation and preventive maintenance of laboratory equipment.
  • Work under general supervision to ensure timely execution of projects.
  • Analyze and communicate experimental results to colleagues and supervisor and provide solutions to problems.
  • Collaborate across functional areas, maintaining a good rapport.
  • Assist with protein inventory management.
  • Other duties as deemed necessary.

 

Required Skills and Qualifications

  • A Bachelor’s Degree and 6 to 8 years of directly relevant industry experience, a Master’s Degree with 4 to 6 years of directly relevant industry experience, or a PhD with 1 to 2 years of directly relevant industry experience is required. A BSc, MSc or PhD in Cell and Molecular Biology, Biochemistry, or a related discipline is preferred.

 

  • Demonstrated technical proficiency, scientific creativity, collaboration with others, and independent thought in suggesting experimental design is required.
  • The ideal candidate will have experience in the following:
    • AKTA Chromatography and filtration unit operations
    • Large molecule/biologic drug development
    • Authoring of SOP’s and technical reports
  • Working knowledge of different modes of chromatography, types of resins, and column packing.
  • Strong analytical skills with hands-on experience with SDS-PAGE, HPLC, Octet, and TFF/UFDF is strongly preferred.
  • Familiarity with cGMP bioprocessing and experience working with CDMO’s is preferred.
  • Ability to multi-task, prioritize projects, and troubleshoot process and equipment problems.
  • Ability to work in a highly collaborative environment with rapidly evolving priorities.
  • Excellent written and oral communication skills.

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